CRISPR Screens to Discover Functional Noncoding Elements
نویسندگان
چکیده
منابع مشابه
Genome-scale CRISPR pooled screens.
Genome editing technologies such as clustered regularly interspaced short palindromic repeats (CRISPR) systems have ushered in a new era of targeted DNA manipulation. The easy programmability of CRISPR using short oligonucleotides enables rapid synthesis of large-scale libraries for functional genetic screens. Here we present fundamental concepts and methods for pooled CRISPR screens and review...
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ژورنال
عنوان ژورنال: Trends in Genetics
سال: 2016
ISSN: 0168-9525
DOI: 10.1016/j.tig.2016.06.004